17-Alpha Hydroxyprogesterone (17-OHP) Test
What is it?
17-Alpha Hydroxyprogesterone (17-OHP) is a steroid hormone produced in the adrenal glands, ovaries, and testes. It acts as a precursor in the production of cortisol and androgens. A serum test measures 17-OHP levels in the blood to evaluate adrenal and reproductive health.
Uses of the Test
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Screening for Congenital Adrenal Hyperplasia (CAH):
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CAH is a genetic disorder where the adrenal glands cannot properly produce cortisol.
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Often included in newborn screening programs.
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Diagnosis and Monitoring of Adrenal Disorders:
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Adrenal hyperplasia
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Adrenal tumors
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Evaluation of Androgen Excess in Females:
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Irregular or absent menstruation
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Infertility
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Hirsutism (excessive hair growth)
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Acne or oily skin
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Assessment in Children with Abnormal Puberty:
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Early or delayed puberty
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Rapid growth or abnormal genital development
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Symptoms That May Lead to the Test
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In infants: Ambiguous genitalia, dehydration, vomiting, poor feeding
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In children: Precocious puberty, rapid growth, early closure of growth plates
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In women: Irregular cycles, infertility, hirsutism, deepening voice, acne
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In men: Infertility, signs of adrenal or androgen disorders
Causes of Abnormal Levels
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High 17-OHP levels:
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Congenital adrenal hyperplasia (especially 21-hydroxylase deficiency)
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Adrenal tumors
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Ovarian tumors
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Polycystic Ovary Syndrome (PCOS) – sometimes mildly elevated
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Low 17-OHP levels:
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Adrenal insufficiency (Addison’s disease)
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Underactive adrenal glands
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Certain medications or hormone therapies
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Side Effects / Risks of the Test
Since the test involves a blood sample, risks are minimal and may include:
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Mild pain or bruising at the puncture site
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Rarely, dizziness or infection
Reference Ranges (Approximate, may vary by lab and age)
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Newborns: Can be temporarily high in the first days after birth
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Children: < 110 ng/dL
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Adult women (follicular phase): < 80 ng/dL
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Adult women (luteal phase): < 285 ng/dL
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Adult men: < 220 ng/dL


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